解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
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医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
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公共、环境和职业卫生
放射学,核医学和医学成像
康复学
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呼吸系统
风湿病学
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热带医学
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心理学,临床
abstract::INT131 (formerly T0903131, T131, AMG131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor gamma modulator (SPPARM) currently in Phase 2 clinical trials for treatment of type-2 diabetes mellitus (T2DM). This new chemical entity represents a second generation SPPARM approach d...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2008/936906
更新日期:2008-01-01 00:00:00
abstract::PPAR isotypes are involved in the regulation of cell proliferation, death, and differentiation, with different roles and mechanisms depending on the specific isotype and ligand and on the differentiated, undifferentiated, or transformed status of the cell. Differentiation stimuli are integrated by key transcription fa...
journal_title:PPAR research
pub_type: 杂志文章,收录出版
doi:10.1155/2007/48242
更新日期:2007-01-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of the women of reproductive age. Familial clustering of PCOS has been consistently reported suggesting that genetic factors play a role in the development of the syndrome although PCOS cases do not exhibit a clear pattern of Mendelian inheritance....
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2007/49109
更新日期:2007-01-01 00:00:00
abstract::Protein farnesylation is required for the activation of multiple proteins involved in cell differentiation and function. In white adipose tissue protein, farnesylation has shown to be essential for the successful differentiation of preadipocytes into adipocytes. We hypothesize that protein farnesylation is required fo...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2007/81654
更新日期:2007-01-01 00:00:00
abstract::Infection with Mycobacterium tuberculosis (TB) induces pulmonary immunopathology mediated by classical Th1 type of acquired immunity with hepatic involvement in up to 80% of disseminated cases. Since PPAR agonists cause immune responses characterized by a decrease in the secretion of Th1 cytokines, we investigated the...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2007/49671
更新日期:2007-01-01 00:00:00
abstract::Inflammation is a major component in the pathology of chronic lung diseases, including asthma. Anti-inflammatory treatment with corticosteroids is not effective in all patients. Thus, new therapeutic options are required to control diverse cellular functions that are currently not optimally targeted by these drugs in ...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/2007/14983
更新日期:2007-01-01 00:00:00
abstract::It has been proposed that PPAR-dependent, accelerated catabolism of proinflammatory mediators may contribute to the fast resolution of inflammation. Because retinoid X receptors are obligate heterodimer partners of PPARs, we investigated the impact of deleting hepatocyte-specific RXRalpha on the antiedema effect of PP...
journal_title:PPAR research
pub_type: 杂志文章
doi:10.1155/PPAR/2006/96341
更新日期:2006-01-01 00:00:00